Kisspeptin

Research-grade kisspeptin is typically supplied as a lyophilized (freeze-dried) white powder with purity ≥98% as confirmed by HPLC analysis. Molecular weight and sequence identity are verified by mass spectrometry. A certificate of analysis (CoA) is provided with each lot.

Kisspeptin has been studied across a wide range of preclinical models, including rodent (mouse and rat) in vivo experiments, ovine and non-human primate neuroendocrine studies, primary hypothalamic neuron cultures, GnRH-secreting cell lines (e.g., GT1-7), and various cancer cell lines (e.g., MDA-MB-435, PANC-1). Ex vivo brain slice electrophysiology preparations have also been widely employed.

Kisspeptin acts as the endogenous ligand for GPR54 (also known as KISS1R), a Gαq/11-coupled seven-transmembrane receptor. Receptor binding research has characterized downstream activation of phospholipase C-β, IP3-mediated calcium mobilization, ERK1/2 phosphorylation, and inhibition of voltage-gated potassium channels in expressing cell systems.

No. This product is supplied strictly for in vitro laboratory research and preclinical investigational use only. It is not approved, tested, or intended for human administration, veterinary use, or any therapeutic, diagnostic, or food-related application.